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Reovirus antigen was detected in pancreatic islets of T3A-infected mice, and primary cultures of pancreatic islets from NOD mice supported T3A growth. Significantly fewer T3A-infected animals compared to uninfected controls developed diabetes. However, despite the alteration in diabetes penetrance, insulitis was evident in T3A-infected mice. These results suggest that viral infection of NOD mice alters autoimmune responses to \u03b2-cell antigens and thereby delays development of diabetes.<\/jats:p>","DOI":"10.1128\/jvi.80.6.3078-3082.2006","type":"journal-article","created":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T20:47:54Z","timestamp":1140814074000},"page":"3078-3082","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Reovirus Delays Diabetes Onset but Does Not Prevent Insulitis in Nonobese Diabetic Mice"],"prefix":"10.1128","volume":"80","author":[{"given":"J. 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