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Mucins serve various functions, but importantly they aid in the clearance of pathogens and debris from epithelial barriers and serve as innate immune factors. In this study, we describe a requirement of host monosaccharides, likely derived from host mucins, for the ability of\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            to colonize the intestine and ultimately cause death in\n            <jats:named-content content-type=\"genus-species\">Caenorhabditis elegans<\/jats:named-content>\n            . We also demonstrate that monosaccharides alter the ability of bacteria to bind to both\n            <jats:named-content content-type=\"genus-species\">Caenorhabditis elegans<\/jats:named-content>\n            intestinal cells and human lung alveolar epithelial cells, suggesting that there are conserved mechanisms underlying host-pathogen interactions in a range of organisms. By gaining a better understanding of pathogen-mucin interactions, we can develop better approaches to protect against pathogen infection.\n          <\/jats:p>","DOI":"10.1128\/mbio.00060-20","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T10:09:31Z","timestamp":1582970971000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Host Mucin Is Exploited by Pseudomonas aeruginosa To Provide Monosaccharides Required for a Successful Infection"],"prefix":"10.1128","volume":"11","author":[{"given":"Casandra L.","family":"Hoffman","sequence":"first","affiliation":[{"name":"Molecular Microbiology and Immunology Department, Oregon Health and Sciences University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lalsiamthara","sequence":"additional","affiliation":[{"name":"Molecular Microbiology and Immunology Department, Oregon Health and Sciences University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Aballay","sequence":"additional","affiliation":[{"name":"Molecular Microbiology and Immunology Department, Oregon Health and Sciences University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003952"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0581-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007015312036"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.12.5417-5420.1996"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.3890"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-018-0067-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b01467"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00073-12"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2010.01461.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00112"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/018622-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00238"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.657114"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.24.8213-8220.2004"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2007.02.004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00383.2001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/154.4_Pt_2.S183"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.01.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12910"},{"key":"e_1_3_3_22_2","first-page":"324","article-title":"Mucus pathophysiology in COPD: differences to asthma, and pharmacotherapy","volume":"55","author":"Rogers DF","year":"2005","unstructured":"Rogers DF. 2005. 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