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People affected by\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            infection include patients with a weakened immune system, such as those with cystic fibrosis (CF) genetic disease or non-CF bronchiectasis. Disease outcomes range from fatal pneumonia to chronic life-threatening infection and inflammation leading to the progressive deterioration of pulmonary function. The development of these respiratory infections is mediated by multiple causes. However, the genetic factors underlying infection susceptibility are poorly known and difficult to predict. Our study employed novel approaches and improved mouse disease models to identify genetic modifiers that affect the severity of\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            lung infection. 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