{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:56:57Z","timestamp":1777193817855,"version":"3.51.4"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Beijing Municipal Natural Science Foundation","award":["M21001"],"award-info":[{"award-number":["M21001"]}]},{"name":"Start-up Foundation of Tsinghua University","award":["53332101319"],"award-info":[{"award-number":["53332101319"]}]},{"name":"Tsinghua University Spring Breeze Fund","award":["2021Z99CFY030"],"award-info":[{"award-number":["2021Z99CFY030"]}]},{"name":"Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory, CAS","award":["2021ACCP-MS03"],"award-info":[{"award-number":["2021ACCP-MS03"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070153"],"award-info":[{"award-number":["32070153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,4,26]]},"abstract":"<jats:p>SARS-CoV-2, the causative agent of pandemic COVID-19, is rapidly evolving to be more transmissible and to exhibit evasive immune properties, compromising neutralization by antibodies from vaccinated individuals or convalescent-phase sera. Recently, SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 with mutations within the spike proteins were identified in India.<\/jats:p>","DOI":"10.1128\/mbio.00099-22","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T13:34:42Z","timestamp":1646919282000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion"],"prefix":"10.1128","volume":"13","author":[{"given":"Wenlin","family":"Ren","sequence":"first","affiliation":[{"name":"Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Ju","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingli","family":"Gong","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lan","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanying","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-2798","authenticated-orcid":true,"given":"Quanxin","family":"Long","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin J.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA"},{"name":"National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoife K.","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA"},{"name":"National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3554-1275","authenticated-orcid":true,"given":"Jin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-9575","authenticated-orcid":true,"given":"Guocai","family":"Zhong","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory, Shenzhen, China"},{"name":"School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Douam","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA"},{"name":"National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinquan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailong","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Molecular Virology (MOE\/NHC\/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-869X","authenticated-orcid":true,"given":"Qiang","family":"Ding","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.02.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30185-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2015.06.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025373118"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2380-z"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2798-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.027"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.050"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc4730"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.043"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2895-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001584"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.012"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.037"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.013"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00573-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","unstructured":"Cherian S Potdar V Jadhav S Yadav P Gupta N Das M Das S Agarwal A Singh S Abraham P Panda S Mande S Swarup R Bhargava B Bhushan R NIC Team INSACOG Consortium. 2021. Convergent evolution of SARS-CoV-2 spike mutations L452R E484Q and P681R in the second wave of COVID-19 in Maharashtra India. bioRxiv https:\/\/www.biorxiv.org\/content\/10.1101\/2021.04.22.440932v1.","DOI":"10.1101\/2021.04.22.440932"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"Tada T Zhou H Dcosta BM Samanovic MI Mulligan MJ Landau NR. 2021. The spike proteins of SARS-CoV-2 B.1.617 and B.1.618 variants identified in India provide partial resistance to vaccine-elicited and therapeutic monoclonal antibodies. bioRxiv https:\/\/www.biorxiv.org\/content\/10.1101\/2021.05.14.444076v1.","DOI":"10.1101\/2021.05.14.444076"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","unstructured":"McCallum M Bassi J De Marco A Chen A Walls AC Di Iulio J Tortorici MA Navarro M-J Silacci-Fregni C Saliba C Agostini M Pinto D Culap K Bianchi S Jaconi S Cameroni E Bowen JE Tilles SW Pizzuto MS Bernasconi Guastalla S Bona G Franzetti Pellanda A Garzoni C Van Voorhis WE Rosen LE Snell G Telenti A Virgin HW Piccoli L Corti D Veesler D. 2021. SARS-CoV-2 immune evasion by variant B.1.427\/B.1.429. bioRxiv https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.31.437925v1.","DOI":"10.1101\/2021.03.31.437925"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.06.006"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27062"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01318-5"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03471-w"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.03.009"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009246"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21213-4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002589117"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00958-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11046"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106267"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01283-20"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009392"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.025"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.011"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.004"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2104241118"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-021-00847-6"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03777-9"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009439"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.00099-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.00099-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T13:35:29Z","timestamp":1650980129000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.00099-22"}},"subtitle":[],"editor":[{"given":"Xiang-Jin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4,26]]}},"alternative-id":["10.1128\/mbio.00099-22"],"URL":"https:\/\/doi.org\/10.1128\/mbio.00099-22","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"2022-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00099-22"}}