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We employed a computational approach to assess the risk of antibody escape resulting from mutations in the receptor-binding domain of the spike protein of the wild-type SARS-CoV-2 virus as well as the Delta, Gamma, and Omicron variants.<\/jats:p>","DOI":"10.1128\/mbio.00135-22","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T12:35:41Z","timestamp":1647347741000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape"],"prefix":"10.1128","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-8505","authenticated-orcid":true,"given":"Nash D.","family":"Rochman","sequence":"first","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9537-2277","authenticated-orcid":true,"given":"Guilhem","family":"Faure","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0247-8708","authenticated-orcid":true,"given":"Yuri I.","family":"Wolf","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-4226","authenticated-orcid":true,"given":"Lydia","family":"Freddolino","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA"},{"name":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-7995","authenticated-orcid":true,"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-8299","authenticated-orcid":true,"given":"Eugene V.","family":"Koonin","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","unstructured":"Zhan SH Deverman BE Chan YA. 2020. 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