{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:57:57Z","timestamp":1769014677652,"version":"3.49.0"},"reference-count":82,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,4,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              A comprehensive microbial surveillance was conducted at NASA\u2019s Mars 2020 spacecraft assembly facility (SAF), where whole-genome sequencing (WGS) of 110 bacterial strains was performed. One isolate, designated 179-BFC-A-HS\n              <jats:sup>T<\/jats:sup>\n              , exhibited less than 80% average nucleotide identity (ANI) to known species, suggesting a novel organism. This strain demonstrated high-level resistance [minimum inhibitory concentration (MIC) &gt;256 mg\/L] to third-generation cephalosporins, including ceftazidime, cefpodoxime, combination ceftazidime\/avibactam, and the fourth-generation cephalosporin cefepime. The results of a comparative genomic analysis revealed that 179-BFC-A-HS\n              <jats:sup>T<\/jats:sup>\n              is most closely related to\n              <jats:italic>Virgibacillus halophilus<\/jats:italic>\n              5B73C\n              <jats:sup>T<\/jats:sup>\n              <jats:italic>,<\/jats:italic>\n              sharing an ANI of 78.7% and a digital DNA-DNA hybridization (dDDH) value of 23.5%, while their 16S rRNA gene sequences shared 97.7% nucleotide identity. Based on these results and the recent recognition that the genus\n              <jats:italic>Virgibacillus<\/jats:italic>\n              is polyphyletic, strain 179-BFC-A-HS\n              <jats:sup>T<\/jats:sup>\n              is proposed as a novel species of a novel genus,\n              <jats:italic>Tigheibacillus jepli<\/jats:italic>\n              gen. nov., sp. nov (type strain 179-BFC-A-HS\n              <jats:sup>T<\/jats:sup>\n              = DSM 115946\n              <jats:sup>T<\/jats:sup>\n              = NRRL B-65666\n              <jats:sup>T<\/jats:sup>\n              ), and its closest neighbor,\n              <jats:italic>V. halophilus<\/jats:italic>\n              , is proposed to be reassigned to this genus as\n              <jats:italic>Tigheibacillus halophilus<\/jats:italic>\n              comb. nov. (type strain 5B73C\n              <jats:sup>T<\/jats:sup>\n              = DSM 21623\n              <jats:sup>T<\/jats:sup>\n              = JCM 21758\n              <jats:sup>T<\/jats:sup>\n              = KCTC 13935\n              <jats:sup>T<\/jats:sup>\n              ). It was also necessary to reclassify its second closest neighbor\n              <jats:italic>Virgibacillus soli,<\/jats:italic>\n              as a member of a novel genus\n              <jats:italic>Paracerasibacillus<\/jats:italic>\n              , reflecting its phylogenetic position relative to the genus\n              <jats:italic>Cerasibacillus<\/jats:italic>\n              , for which we propose\n              <jats:italic>Paracerasibacillus soli<\/jats:italic>\n              comb. nov. (type strain CC-YMP-6\n              <jats:sup>T<\/jats:sup>\n              = DSM 22952\n              <jats:sup>T<\/jats:sup>\n              = CCM 7714\n              <jats:sup>T<\/jats:sup>\n              ). Within\n              <jats:italic>Amphibacillaceae<\/jats:italic>\n              (\n              <jats:italic>n<\/jats:italic>\n              = 64),\n              <jats:italic>P. soli<\/jats:italic>\n              exhibited 11 antibiotic resistance genes (ARG), while\n              <jats:italic>T. jepli<\/jats:italic>\n              encoded for 3, lacking any known \u03b2-lactamases, suggesting resistance from variant penicillin-binding proteins, disrupting cephalosporin efficacy.\n              <jats:italic>P. soli<\/jats:italic>\n              was highly resistant to azithromycin (MIC &gt;64 mg\/L) yet susceptible to cephalosporins and penicillins.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              The significance of this research extends to understanding microbial survival and adaptation in oligotrophic environments, such as those found in SAF. Whole-genome sequencing of several strains isolated from Mars 2020 mission assembly cleanroom facilities, including the discovery of the novel species\n              <jats:italic>Tigheibacillus jepli<\/jats:italic>\n              , highlights the resilience and antimicrobial resistance (AMR) in clinically relevant antibiotic classes of microbes in nutrient-scarce settings. The study also redefines the taxonomic classifications within the\n              <jats:italic>Amphibacillaceae<\/jats:italic>\n              family, aligning genetic identities with phylogenetic data. Investigating ARG and virulence factors (VF) across these strains illuminates the microbial capability for resistance under resource-limited conditions while emphasizing the role of human-associated VF in microbial survival, informing sterilization practices and microbial management in similar oligotrophic settings beyond spacecraft assembly cleanrooms such as pharmaceutical and medical industry cleanrooms.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.00181-24","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T17:25:19Z","timestamp":1710696319000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Novel spore-forming species exhibiting intrinsic resistance to third- and fourth-generation cephalosporins and description of\n            <i>Tigheibacillus jepli<\/i>\n            gen. nov., sp. 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