{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:16:55Z","timestamp":1777652215665,"version":"3.51.4"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI39558"],"award-info":[{"award-number":["AI39558"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI113187"],"award-info":[{"award-number":["AI113187"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,4,28]]},"abstract":"<jats:p><jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>is an important mucosal pathogen that is the leading cause of sexually transmitted bacterial infections in the United States. Despite this, there is no vaccine currently available. In order to develop such a vaccine, it is necessary to understand the components of the immune response that can lead to protection against this pathogen. It is well known that antigen-specific CD4<jats:sup>+<\/jats:sup>T cells are critical for<jats:italic>Chlamydia<\/jats:italic>clearance, but the contexts in which they are protective or not protective are unknown. Here, we aimed to characterize the importance of gamma interferon production and sensing by T cells and the effects on the immune response to<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>. Our work here helps to define the contexts in which antigen-specific T cells can be protective, which is critical to our ability to design an effective and protective vaccine against<jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>.<\/jats:p>","DOI":"10.1128\/mbio.00191-20","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T12:01:10Z","timestamp":1584360070000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Gamma Interferon Is Required for<i>Chlamydia<\/i>Clearance but Is Dispensable for T Cell Homing to the Genital Tract"],"prefix":"10.1128","volume":"11","author":[{"given":"Jennifer D.","family":"Helble","sequence":"first","affiliation":[{"name":"Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich H.","family":"von Andrian","sequence":"additional","affiliation":[{"name":"Department of Immunology, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Starnbach","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Disease Control and Prevention. 2017. 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Distinct homing pathways direct T lymphocytes to the genital and intestinal mucosae in Chlamydia-infected mice. J Immunol 160:2905\u20132914.","journal-title":"J Immunol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.12.5198-5208.1997"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711356115"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103032"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900295"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1997.d01-167.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.158.7.3344","article-title":"Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways","volume":"158","author":"Perry LL","year":"1997","unstructured":"Perry LL, Feilzer K, Caldwell HD. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. J Immunol 158:3344\u20133352.","journal-title":"J Immunol"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.4049\/jimmunol.162.6.3541","article-title":"Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibition","volume":"162","author":"Perry LL","year":"1999","unstructured":"Perry LL, Su H, Feilzer K, Messer R, Hughes S, Whitmire W, Caldwell HD. 1999. Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibition. 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