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We have found that human macrophages can recognize invading yeast pathogens that have a specific molecular pattern of proteins on their surfaces: these proteins have structures similar to the structures of amyloid aggregates in neurodegenerative diseases like Alzheimer\u2019s disease. However, this surface pattern also causes the fungi to bind a serum protein called serum amyloid P component (SAP). In turn, the SAP-coated yeasts are poorly recognized and seldom ingested by the macrophages, and the macrophages have a more tolerant and less inflammatory response in the presence of SAP. Therefore, we find that surface structures on the yeast can alter how the macrophages react to invading microbes.<\/jats:p>","DOI":"10.1128\/mbio.00218-19","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T10:43:59Z","timestamp":1552301039000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines"],"prefix":"10.1128","volume":"10","author":[{"given":"Nicole E.","family":"Behrens","sequence":"first","affiliation":[{"name":"Department of Immunobiology, University of Arizona, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N.","family":"Lipke","sequence":"additional","affiliation":[{"name":"Department of Biology, Brooklyn College, Brooklyn, New York, USA"},{"name":"Graduate Center of the City University of New York, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell","family":"Pilling","sequence":"additional","affiliation":[{"name":"Department of Biology, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Gomer","sequence":"additional","affiliation":[{"name":"Department of Biology, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Klotz","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Arizona, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90090-Y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2013.01.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401998"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.4.1753-1759.2000"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14584"},{"key":"e_1_3_3_7_2","first-page":"637","volume-title":"Samter's immunological diseases","author":"Pepys MB","year":"1994","unstructured":"Pepys MB. 1994. 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