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Certain\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            strains cause ocular disease, while others cause upper genital tract pathology. However, little is known about the cellular or immunologic basis for these differences. Here, we compared the abilities of the strain types to infect, replicate, and initiate an immune response in primary human ocular and urogenital epithelial cells, as well as in fibroblasts from the underlying stroma. While there were no significant differences in infection rates or intracellular growth for any strain in any cell type, proinflammatory responses were driven not by the epithelial cells but by fibroblasts and were distinct between ocular and urogenital strains. Our findings suggest that primary fibroblasts are a novel and more appropriate model for studies of immune responses that will expand our understanding of the differential pathological disease outcomes caused by various\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            strain types.\n          <\/jats:p>","DOI":"10.1128\/mbio.00225-19","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T11:21:19Z","timestamp":1552908079000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Stromal Fibroblasts Drive Host Inflammatory Responses That Are Dependent on Chlamydia trachomatis Strain Type and Likely Influence Disease Outcomes"],"prefix":"10.1128","volume":"10","author":[{"given":"Amber Leah","family":"Jolly","sequence":"first","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameeha","family":"Rau","sequence":"additional","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmol K.","family":"Chadha","sequence":"additional","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekhlas Ahmed","family":"Abdulraheem","sequence":"additional","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Dean","sequence":"additional","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, California, USA"},{"name":"Department of Bioengineering, University of California at Berkeley, Berkeley, California, USA"},{"name":"Department of Medicine and Pediatrics, University of California at San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"678","volume-title":"Duane\u2019s foundations of clinical ophthalmology","author":"Dean D","year":"2010","unstructured":"Dean D. 2010. 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