{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:05Z","timestamp":1787016725639,"version":"build-2736575974"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21-AI118519"],"award-info":[{"award-number":["R21-AI118519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["and R01-GM084383"],"award-info":[{"award-number":["and R01-GM084383"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,4,30]]},"abstract":"<jats:p>\n                    Because oxygen plays a key role in the growth of many organisms, cells must know how much oxygen is available. O\n                    <jats:sub>2<\/jats:sub>\n                    -sensing proteins are therefore critical cellular factors, and prolyl hydroxylases are the best-studied type of O\n                    <jats:sub>2<\/jats:sub>\n                    -sensing proteins. In general, prolyl hydroxylases trigger cellular responses to decreased oxygen availability. But, how does a cell react to high levels of oxygen? Using the protozoan parasite\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    , we discovered a prolyl hydroxylase that allows the parasite to grow at elevated oxygen levels and does so by regulating protein synthesis. Loss of this enzyme also reduces parasite burden in oxygen-rich tissues, indicating that sensing both high and low levels of oxygen impacts the growth and physiology of\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/mbio.00234-19","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T07:00:34Z","timestamp":1553497234000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["A\n                    <i>Toxoplasma<\/i>\n                    Prolyl Hydroxylase Mediates Oxygen Stress Responses by Regulating Translation Elongation"],"prefix":"10.1128","volume":"10","author":[{"given":"Celia","family":"Florimond","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, 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