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Our data suggest that it is essential that we understand the basic principles of how to drive optimum repertoires for both TCR chains, \u03b1 and \u03b2. We address this important issue by characterizing the CD8 TCR repertoire to a common persistent human viral infection (EBV), which is controlled by appropriate CD8 T cell responses. The ultimate goal would be to determine if the individuals who are infected asymptomatically develop a different TCR repertoire than those that develop the immunopathology of AIM. Here, we begin by doing an in-depth characterization of both CD8 T cell TCR\u03b1 and TCR\u03b2 repertoires to two immunodominant EBV epitopes over the course of AIM, identifying potential factors that may be driving their selection.<\/jats:p>","DOI":"10.1128\/mbio.00250-20","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T08:01:10Z","timestamp":1584345670000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Epstein-Barr Virus Epitope\u2013Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor \u03b1 and \u03b2 Repertoires"],"prefix":"10.1128","volume":"11","author":[{"given":"Anna","family":"Gil","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Kamga","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramakanth","family":"Chirravuri-Venkata","sequence":"additional","affiliation":[{"name":"School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fransenio","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Ghersi","sequence":"additional","affiliation":[{"name":"School of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, Nebraska, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Luzuriaga","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa K.","family":"Selin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112326"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001116"},{"key":"e_1_3_3_4_2","first-page":"1147","article-title":"Antibodies to Epstein-Barr virus in Burkitt\u2019s lymphoma and control groups","volume":"43","author":"Henle G","year":"1969","unstructured":"Henle G, Henle W, Clifford P, Diehl V, Kafuko GW, Kirya BG, Klein G, Morrow RH, Munube GM, Pike P, Tukei PM, Ziegler JL. 1969. 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