{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:52:15Z","timestamp":1791532335403,"version":"4.3.4"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003074","name":"MINCyT | Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2011-2672"],"award-info":[{"award-number":["PICT 2011-2672"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"MINCyT | Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2014-0959"],"award-info":[{"award-number":["PICT 2014-0959"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"MINCyT | Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016-1618"],"award-info":[{"award-number":["PICT 2016-1618"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY024363"],"award-info":[{"award-number":["R01EY024363"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017011","name":"Chicago Biomedical Consortium","doi-asserted-by":"publisher","award":["C-086"],"award-info":[{"award-number":["C-086"]}],"id":[{"id":"10.13039\/100017011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,4,27]]},"abstract":"<jats:p>Bacteria employ two-component systems (TCSs) to sense and respond to changes in their surroundings. At the core of the TCS signaling pathway is the multidomain sensor histidine kinase, where the enzymatic activity of its output domain is allosterically controlled by the input signal perceived by the sensor domain.<\/jats:p>","DOI":"10.1128\/mbio.00264-21","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T14:35:22Z","timestamp":1618842922000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Dimer Asymmetry and Light Activation Mechanism in\n            <i>Brucella<\/i>\n            Blue-Light Sensor Histidine Kinase"],"prefix":"10.1128","volume":"12","author":[{"given":"Jimena","family":"Rinaldi","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heewhan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Sycz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semini","family":"Gunawardana","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indika","family":"Kumarapperuma","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Paz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisandro H.","family":"Otero","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"},{"name":"Plataforma Argentina de Biolog\u00eda Estructural y Metabol\u00f3mica PLABEM, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Cerutti","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"},{"name":"Plataforma Argentina de Biolog\u00eda Estructural y Metabol\u00f3mica PLABEM, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Zorreguieta","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8777-0870","authenticated-orcid":true,"given":"Sebasti\u00e1n","family":"Klinke","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"},{"name":"Plataforma Argentina de Biolog\u00eda Estructural y Metabol\u00f3mica PLABEM, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-9189","authenticated-orcid":true,"given":"Xiaojing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois, USA"},{"name":"Department of Ophthalmology and Vision Sciences, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-3002","authenticated-orcid":true,"given":"Fernando A.","family":"Goldbaum","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina"},{"name":"Plataforma Argentina de Biolog\u00eda Estructural y Metabol\u00f3mica PLABEM, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091018-054627"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0055-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12209"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144306"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi100527a"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121292109"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.108977"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi400617y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038226"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi1006404"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413983111"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00334-13"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-112414-054813"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14310"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2017.01.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12809"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124058"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2622"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3705"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00300-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2017.04.006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1813586116"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086810"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100262108"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.04.006"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004715007622"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.01.026"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4258"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001776"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.01.056"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.04.024"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.04.012"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.05.027"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001493"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2018.09.005"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444913003454"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2017.04.011"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600886"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.12.006"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798317013043"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13118"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1602498"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34815"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910855116"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906699106"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi992921w"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.147843"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.012757"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013081107"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02310-9"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003084"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2010.06.016"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1318"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2005.01.016"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912001308"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909042073"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(97)76066-X"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_3_2_61_2","volume-title":"PyMOL","author":"DeLano WL","year":"2002","unstructured":"DeLano WL. 2002. PyMOL. DeLano Scientific, San Carlos, CA."},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.022"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.01.002"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00264-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00264-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:24:11Z","timestamp":1646709851000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.00264-21"}},"subtitle":[],"editor":[{"given":"Michael T.","family":"Laub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4,27]]}},"alternative-id":["10.1128\/mBio.00264-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.00264-21","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]},"assertion":[{"value":"2021-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00264-21"}}