{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:17:49Z","timestamp":1785439069787,"version":"3.56.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI121124"],"award-info":[{"award-number":["R01AI121124"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,4,28]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Ehrlichia chaffeensis<\/jats:named-content>\n            is an obligatory intracellular bacterium with the capability of causing an emerging infectious disease called human monocytic ehrlichiosis.\n            <jats:italic>E. chaffeensis<\/jats:italic>\n            preferentially infects monocytes and macrophages, professional phagocytes, equipped with an arsenal of antimicrobial mechanisms, including rapid reactive oxygen species (ROS) generation upon encountering bacteria. As\n            <jats:italic>Ehrlichia<\/jats:italic>\n            isolated from host cells are readily killed upon exposure to ROS,\n            <jats:italic>Ehrlichia<\/jats:italic>\n            must have evolved a unique mechanism to safely enter phagocytes. We discovered that binding of the\n            <jats:italic>Ehrlichia<\/jats:italic>\n            surface invasin to the host cell surface receptor not only triggers\n            <jats:italic>Ehrlichia<\/jats:italic>\n            entry but also blocks ROS generation by the host cells by mobilizing a novel intracellular signaling pathway. Knowledge of the mechanisms by which ROS production is inhibited may lead to the development of therapeutics for ehrlichiosis as well as other ROS-related pathologies.\n          <\/jats:p>","DOI":"10.1128\/mbio.00267-20","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T15:03:49Z","timestamp":1587395029000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation"],"prefix":"10.1128","volume":"11","author":[{"given":"Omid","family":"Teymournejad","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Rikihisa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01541-15"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.89"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.151555"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.32.020181.001525"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00835.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020021"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01551-17"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1533"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)80886-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80019-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302208200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.05.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31748-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3550851"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19108"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des050"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.45.1.1-5.1984"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708566200"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003666"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/385169a0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.17.3.1346"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.22.6608"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2741\/A766"},{"key":"e_1_3_2_25_2","first-page":"611","article-title":"The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization","volume":"7","author":"Adams JM","year":"1992","unstructured":"Adams JM, Houston H, Allen J, Lints T, Harvey R. 1992. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. Oncogene 7:611\u2013618.","journal-title":"Oncogene"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.04.004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.01.026"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02316.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvv127"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10606"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02168-09"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111583198"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3563"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.016980"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.71.9.5324-5331.2003"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4425"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.20.5.1678-1691.2000"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.033"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004993"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.68.12.6697-6703.2000"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.3.1359-1366.2002"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1086\/341451"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708281200"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-0859"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.7009"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00367-07"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02676.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9219.2004.00184.x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311680110"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.29.12.2741-2745.1991"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02028-06"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.11.4804-4810.1994"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01775.x"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(76)90181-6"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-1759(99)00146-5"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00267-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00267-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T02:50:31Z","timestamp":1646707831000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.00267-20"}},"subtitle":[],"editor":[{"given":"Tian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Andrew B.","family":"Onderdonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4,28]]}},"alternative-id":["10.1128\/mBio.00267-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.00267-20","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]},"assertion":[{"value":"2020-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00267-20"}}