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One of these adaptations is the accumulation of multiple siderophore systems, which scavenge iron for nutritional use. While iron uptake is important for bacterial growth, the increased metabolic costs of siderophore production could diminish bacterial fitness during infections. In a siderophore-dependent growth condition, we show that the virulence-associated yersiniabactin siderophore system in uropathogenic\n            <jats:italic>E. coli<\/jats:italic>\n            is not redundant with the ubiquitous\n            <jats:italic>E. coli<\/jats:italic>\n            enterobactin system. This arises not from differences in iron-scavenging activity but because yersiniabactin is preferentially expressed during bacterial crowding, leaving bacteria dependent upon enterobactin for growth at low cell density. Notably, this regulatory mode arises because yersiniabactin stimulates its own expression, acting as an autoinducer in a previously unappreciated quorum-sensing system. This unexpected result connects quorum-sensing with pathogenic potential in\n            <jats:italic>E. coli<\/jats:italic>\n            and related\n            <jats:italic>Enterobacterales<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/mbio.00277-23","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:00:15Z","timestamp":1705586415000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Yersiniabactin is a quorum-sensing autoinducer and siderophore in uropathogenic\n            <i>Escherichia coli<\/i>"],"prefix":"10.1128","volume":"15","author":[{"given":"James R.","family":"Heffernan","sequence":"first","affiliation":[{"name":"Center for Women\u2019s Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Division of Infectious Diseases, Washington University School of Medicine, St. Louis, 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