{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:30:02Z","timestamp":1771655402976,"version":"3.50.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["AI143707"],"award-info":[{"award-number":["AI143707"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["AI120607"],"award-info":[{"award-number":["AI120607"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,4,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              <jats:italic>Toxoplasma gondii<\/jats:italic>\n              is a widespread intracellular protozoan pathogen infecting virtually all warm-blooded animals. This parasite acquires host-derived resources to support its replication inside a membrane-bound parasitophorous vacuole within infected host cells. Previous research has discovered that\n              <jats:italic>Toxoplasma<\/jats:italic>\n              actively endocytoses host proteins and transports them to a lysosome-equivalent structure for digestion. However, few molecular determinants required for trafficking of host-derived material within the parasite were known. A recent study (Q.-Q. Wang, M. Sun, T. Tang, D.-H. Lai, et al., mBio 14:e01309-23, 2023,\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/mbio.01309-23\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/mbio.01309-23<\/jats:ext-link>\n              ) identified a critical role for membrane anchoring of proteins via prenylation in the trafficking of endocytosed host proteins by\n              <jats:italic>Toxoplasma<\/jats:italic>\n              , including an essential\n              <jats:italic>Toxoplasma<\/jats:italic>\n              ortholog of Rab1B. The authors also found that TgRab1 is crucial for protein trafficking of the rhoptry secretory organelles, indicating a dual role in endocytic and exocytic protein trafficking. This study sets the stage for further dissecting endomembrane trafficking in\n              <jats:italic>Toxoplasma<\/jats:italic>\n              , along with potentially exploiting protein prenylation as a target for therapeutic development.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.00283-24","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T14:00:32Z","timestamp":1708956032000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Deciphering protein prenylation in endocytic trafficking in\n            <i>Toxoplasma gondii<\/i>"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6859-8895","authenticated-orcid":true,"given":"Vern B.","family":"Carruthers","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-1181","authenticated-orcid":true,"given":"Zhicheng","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.3.607-623.2000"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-011720-122318"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9122592"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.04.003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011543"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.056"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201701108"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.260159"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01188-14"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010138"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37431-x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36571-4"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12556"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00869-19"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202105120"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/21541248.2017.1299270"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(01)02483-8"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01309-23"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112087"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.187"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59384"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.96"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.00283-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.00283-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:06:27Z","timestamp":1712754387000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.00283-24"}},"subtitle":[],"editor":[{"given":"Louis M.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,10]]}},"alternative-id":["10.1128\/mbio.00283-24"],"URL":"https:\/\/doi.org\/10.1128\/mbio.00283-24","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"2024-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00283-24"}}