{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:14Z","timestamp":1792787234348,"version":"4.5.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft","award":["HA 8037\/2-1"],"award-info":[{"award-number":["HA 8037\/2-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["GO 489\/7-1"],"award-info":[{"award-number":["GO 489\/7-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["SCHU 2446\/6-1"],"award-info":[{"award-number":["SCHU 2446\/6-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["KA 3492\/9-1"],"award-info":[{"award-number":["KA 3492\/9-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Marek\u2019s disease virus (MDV) is an oncogenic alphaherpesvirus that causes deadly lymphomas in chickens. In chickens, up to 50% of all peripheral T cells are gamma delta (\u03b3\u03b4) T cells. Until now, their role in MDV pathogenesis and tumor formation remains poorly understood. To investigate the role of \u03b3\u03b4 T cells in MDV pathogenesis, we infected recently generated \u03b3\u03b4 T cell knockout chickens with very virulent MDV. Strikingly, disease and tumor incidence were highly increased in the absence of \u03b3\u03b4 T cells, indicating that \u03b3\u03b4 T cells play an important role in the immune response against MDV. In the absence of \u03b3\u03b4 T cells, virus replication was drastically increased in the thymus and spleen, which are potential sites of T cell transformation. Taken together, our data provide the first evidence that \u03b3\u03b4 T cells play an important role in the pathogenesis and tumor formation of this highly oncogenic herpesvirus.<\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>Gamma delta (\u03b3\u03b4) T cells are the most abundant T cells in chickens, but their role in fighting pathogens remains poorly understood. Marek\u2019s disease virus (MDV) is an important veterinary pathogen, that causes one of the most frequent cancers in animals and is used as a model for virus-induced tumor formation. Our study revealed that \u03b3\u03b4 T cells play a crucial role in combating MDV, as disease and tumor incidence drastically increased in the absence of these cells. \u03b3\u03b4 T cells restricted virus replication in the key lymphoid organs, thereby decreasing the likelihood of causing tumors and disease. This study provides novel insights into the role of \u03b3\u03b4 T cells in the pathogenesis of this highly oncogenic virus.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.00315-24","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T06:19:01Z","timestamp":1719901141000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Unraveling the role of \u03b3\u03b4 T cells in the pathogenesis of an oncogenic avian herpesvirus"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2266-0128","authenticated-orcid":false,"given":"Mohammad A.","family":"Sabsabi","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-8981","authenticated-orcid":false,"given":"Ahmed","family":"Kheimar","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Department of Poultry Diseases, Faculty of Veterinary Medicine, Sohag University","place":["Sohag, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"You","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"von La Roche","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["M\u00fcnchen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"H\u00e4rtle","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["M\u00fcnchen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"G\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["M\u00fcnchen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"von Heyl","sequence":"additional","affiliation":[{"name":"Reproductive Biotechnology, TUM School of Life Sciences, Technische Universit\u00e4t M\u00fcnchen","place":["M\u00fcnchen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-1890","authenticated-orcid":false,"given":"Benjamin","family":"Schusser","sequence":"additional","affiliation":[{"name":"Reproductive Biotechnology, TUM School of Life Sciences, Technische Universit\u00e4t M\u00fcnchen","place":["M\u00fcnchen, Germany"]},{"name":"Center for Infection Prevention (ZIP), Technische Universit\u00e4t M\u00fcnchen","place":["M\u00fcnchen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-2695","authenticated-orcid":true,"given":"Benedikt B.","family":"Kaufer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin","place":["Berlin, Germany"]},{"name":"Veterinary Centre for Resistance Research (TZR), Freie Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","volume-title":"Marek's disease: an evolving problem","author":"Davison F","year":"2004","unstructured":"Davison F, Nair V. 2004. 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