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Recent research has implicated fungal species and their interactions with other organisms in the inflammatory process. New ways to restore microbial balance in the gut are being explored. Our goal was to identify beneficial probiotic strains that would antagonize these fungal and bacterial pathogens that are elevated in the inflamed gut, and which also have antibiofilm activity. Fungus-bacterium correlation analysis allowed us to identify candidate probiotic species that can antagonize microbial pathogens, which we subsequently incorporated into a novel probiotic formulation. Amylase, which is known to have some antibiofilm activity, was also added to the probiotic mixture. This novel probiotic may have utility for the management of inflammatory bowel diseases by disrupting polymicrobial biofilm formation.<\/jats:p>","DOI":"10.1128\/mbio.00338-19","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T10:39:45Z","timestamp":1554719985000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Effects of a Novel Probiotic Combination on Pathogenic Bacterial-Fungal Polymicrobial Biofilms"],"prefix":"10.1128","volume":"10","author":[{"given":"Christopher L.","family":"Hager","sequence":"first","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Isham","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kory P.","family":"Schrom","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Chandra","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"McCormick","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA"},{"name":"University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv209"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000035"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.225"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01250-16"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01058-16"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21921"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/716749"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.009407-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.09.018"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12772"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.04.030"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3314\/mmj.55.J123"},{"key":"e_1_3_3_15_2","first-page":"606","article-title":"Efficacy of probiotics for the management of inflammatory bowel disease","volume":"7","author":"Sartor RB","year":"2011","unstructured":"Sartor RB. 2011. 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