{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:46:38Z","timestamp":1790725598413,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01 AI073289-16, R01 AI145939"],"award-info":[{"award-number":["R01 AI073289-16, R01 AI145939"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2025,4,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Screen of mutants from a mannosyltransferase family identified the importance of\n              <jats:italic>MNT5<\/jats:italic>\n              for\n              <jats:italic>C. auris<\/jats:italic>\n              biofilm drug resistance and neutrophil evasion. Biochemical analysis of the\n              <jats:italic>mnt5\u2206<\/jats:italic>\n              mutant matrix and cell wall identified alterations in the mannan structures. Resistance and matrix for\n              <jats:italic>mnt5\u2206<\/jats:italic>\n              were restored with delivery of wild-type matrix via extracellular vesicles. Analysis of the\n              <jats:italic>mnt5<\/jats:italic>\n              \u2206 cell wall revealed a reduction in mannan and compensatory increase in cell surface glucan and chitin, suggesting a role for\n              <jats:italic>MNT5<\/jats:italic>\n              in mannan masking of pathogen-associated molecular patterns.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              <jats:italic>C. auris<\/jats:italic>\n              recalcitrance is linked to biofilm drug resistance and immune evasion. The mannosyltransferase encoded by\n              <jats:italic>MNT5<\/jats:italic>\n              is necessary for both phenotypes and may serve as a useful therapeutic target.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.00346-25","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:08:27Z","timestamp":1740492507000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Dual function of\n            <i>Candida auris<\/i>\n            mannosyltransferase, MNT5, in biofilm community protection from antifungal therapy and the host"],"prefix":"10.1128","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-1500","authenticated-orcid":true,"given":"Robert","family":"Zarnowski","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison","place":["Madison, USA"]},{"name":"Department of Medical 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