{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:54:50Z","timestamp":1793357690736,"version":"4.5.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 A1058145"],"award-info":[{"award-number":["R01 A1058145"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI131620"],"award-info":[{"award-number":["R01 AI131620"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013114","name":"Broad Institute","doi-asserted-by":"publisher","award":["U19AI110818"],"award-info":[{"award-number":["U19AI110818"]}],"id":[{"id":"10.13039\/100013114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Candida auris<\/jats:named-content>\n                    is an emerging multidrug-resistant pathogen of global concern, known to be responsible for outbreaks on six continents and to be commonly resistant to antifungals. While the vast majority of clinical\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    isolates are highly resistant to fluconazole, an essential part of the available antifungal arsenal, very little is known about the mechanisms contributing to resistance. In this work, we show that mutations in the transcription factor\n                    <jats:italic>TAC1B<\/jats:italic>\n                    significantly contribute to clinical fluconazole resistance. These studies demonstrated that mutations in\n                    <jats:italic>TAC1B<\/jats:italic>\n                    can arise rapidly\n                    <jats:italic>in vitro<\/jats:italic>\n                    upon exposure to fluconazole and that a multitude of resistance-associated\n                    <jats:italic>TAC1B<\/jats:italic>\n                    mutations are present among the majority of fluconazole-resistant\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    isolates from a global collection and appear specific to a subset of lineages or clades. Thus, identification of this novel genetic determinant of resistance significantly adds to the understanding of clinical antifungal resistance in\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/mbio.00365-20","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T09:50:20Z","timestamp":1589190620000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":202,"title":["Mutations in\n                    <i>TAC1B<\/i>\n                    : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-0935","authenticated-orcid":false,"given":"Jeffrey M.","family":"Rybak","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-7957","authenticated-orcid":false,"given":"Jos\u00e9 F.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josie E.","family":"Parker","sequence":"additional","affiliation":[{"name":"Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-4057","authenticated-orcid":false,"given":"Brooke D.","family":"Esquivel","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Missouri at Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Berkow","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Gade","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen E.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore C.","family":"White","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Missouri at Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve L.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Swansea, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5778-960X","authenticated-orcid":false,"given":"Christina A.","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. David","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"e_1_3_2_4_2","unstructured":"Anonymous. 2019. Tracking Candida auris . https:\/\/www.cdc.gov\/fungal\/candida-auris\/tracking-c-auris.html. Accessed 16 January 2020."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2019.103243"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5040111"},{"key":"e_1_3_2_7_2","unstructured":"Anonymous. 2020. Candida auris : antifungal susceptibility testing and interpretation. 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