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Thus, infections caused by\n            <jats:named-content content-type=\"genus-species\">S. maltophilia<\/jats:named-content>\n            pose a big therapeutic challenge. Our study aims to understand the microbiological and molecular characteristics of\n            <jats:named-content content-type=\"genus-species\">S. maltophilia<\/jats:named-content>\n            isolates recovered from human sources. A highlight of the resistance profile of this collection is the excellent activity of the ceftazidime-avibactam and aztreonam combination. We hope this result prompts controlled and observational studies to add clinical data on the utility and safety of this therapy. We also identify 35 and 43 novel variants of L1 and L2, respectively, some of which harbor novel substitutions that could potentially affect substrate and\/or inhibitor binding. 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