{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:40:53Z","timestamp":1765888853187,"version":"3.41.2"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F32AI145157"],"award-info":[{"award-number":["F32AI145157"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,6,28]]},"abstract":"<jats:p>\n            In a recent mBio article, Ayala et al. (mBio 13:e00276-22, 2022,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/mbio.00276-22\">https:\/\/doi.org\/10.1128\/mbio.00276-22<\/jats:ext-link>\n            ) identified a single nucleotide variant in the repressor\n            <jats:italic>gdhR<\/jats:italic>\n            in\n            <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n            that reduces binding to the promoter of the virulence factor\n            <jats:italic>lctP<\/jats:italic>\n            and thereby increases its expression. The allele (\n            <jats:italic>gdhR6<\/jats:italic>\n            ) frequently co-occurs with mutations in the\n            <jats:italic>mtr<\/jats:italic>\n            operon promoter that reduce expression of another repressor,\n            <jats:italic>mtrR<\/jats:italic>\n            , resulting in overexpression of the efflux pump-encoding\n            <jats:italic>mtrCDE<\/jats:italic>\n            and increased antimicrobial resistance.\n          <\/jats:p>","DOI":"10.1128\/mbio.00412-22","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T12:30:42Z","timestamp":1649939442000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Interactions between Loci Contributing to Antimicrobial Resistance and Virulence in Neisseria gonorrhoeae"],"prefix":"10.1128","volume":"13","author":[{"given":"Tatum D.","family":"Mortimer","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Sexually transmitted disease surveillance 2019.","author":"Centers for Disease Control and Prevention","year":"2021","unstructured":"Centers for Disease Control and Prevention. 2021. Sexually transmitted disease surveillance 2019. 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