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Increasing rates of\n            <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n            infection (CDI) in the community suggest exposure to\n            <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n            reservoirs outside the hospital, including animals, the environment, or food.\n            <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n            sequence type 11 (ST11) is known to infect\/colonize livestock worldwide and comprises multiple ribotypes, many of which cause disease in humans, suggesting CDI may be a zoonosis. Using high-resolution genomics, we investigated the evolution and zoonotic potential of ST11 and a new closely related ST258 lineage sourced from diverse origins. We found multiple intra- and interspecies clonal transmission events in all ribotype sublineages. Clones were spread across multiple continents, often without any health care association, indicative of zoonotic\/anthroponotic long-range dissemination in the community. ST11 possesses a massive pan-genome and numerous clinically important antimicrobial resistance elements and prophages, which likely contribute to the success of this globally disseminated lineage of One Health importance.\n          <\/jats:p>","DOI":"10.1128\/mbio.00446-19","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T10:41:36Z","timestamp":1555324896000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":118,"title":["Evolutionary and Genomic Insights into\n            <i>Clostridioides difficile<\/i>\n            Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-4733","authenticated-orcid":false,"given":"Daniel R.","family":"Knight","sequence":"first","affiliation":[{"name":"Medical, Molecular and Forensic Sciences, Murdoch 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