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This therapy generates adverse effects, notably opportunistic infections and activation of viruses from latency. Here, using the infection murine model with the intracellular parasite\n                    <jats:named-content content-type=\"genus-species\">Trypanosoma cruzi<\/jats:named-content>\n                    , we report that anti-CD20 treatment affects not only B cell responses but also CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses, representing the most important immune effectors involved in control of intracellular pathogens. Anti-CD20 treatment, directly or indirectly, affects cytotoxic T cell number and function, and this deficient response was rescued by the cytokine IL-17A. The identification of IL-17A as the cytokine capable of reversing the poor response of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells provides information about a potential therapeutic treatment aimed at enhancing defective immunity induced by B cell depletion.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00447-20","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T09:50:20Z","timestamp":1589190620000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["CD8\n                    <sup>+<\/sup>\n                    T Cell Immunity Is Compromised by Anti-CD20 Treatment and Rescued by Interleukin-17A"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-5598","authenticated-orcid":false,"given":"Facundo","family":"Fiocca Vernengo","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica 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