{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:50:50Z","timestamp":1780055450094,"version":"3.54.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","award":["11KIN01"],"award-info":[{"award-number":["11KIN01"]}],"id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","award":["13KIN01"],"award-info":[{"award-number":["13KIN01"]}],"id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2017,9,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Ophthalmia neonatorum, also called neonatal conjunctivitis, acquired during delivery can occur in the first 28\u00a0days of life. Commonly caused by the bacterial pathogen\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            , infection can lead to corneal scarring, perforation of the eye, and blindness. One approach that can be taken to prevent the disease is the use of an ophthalmic prophylaxis, which kills the bacteria on the surface of the eye shortly after birth. Current prophylaxes are based on antibiotic ointments. However,\n            <jats:italic>N.\u00a0gonorrhoeae<\/jats:italic>\n            is resistant to many antibiotics and alternative treatments must be developed before the condition becomes untreatable. This study focused on developing a fatty acid-based prophylaxis. For this, 37 fatty acids or fatty acid derivatives were screened\n            <jats:italic>in vitro<\/jats:italic>\n            for fast antigonococcal activity. Seven candidates were identified as bactericidal at 1\u00a0mM. These seven were subjected to irritation testing using three separate methods: the bovine corneal opacity and permeability (BCOP) test; the hen\u2019s egg test\u2014chorioallantoic membrane (HET-CAM); and the red blood cell (RBC) lysis assay. The candidates were also tested in artificial tear fluid to determine whether they were effective in this environment. Four of the candidates remained effective. Among these, two lead candidates, monocaprin and myristoleic acid, displayed the best potential as active compounds in the development of a fatty acid-based prophylaxis for prevention of ophthalmia neonatorum.\n          <\/jats:p>","DOI":"10.1128\/mbio.00534-17","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:10:21Z","timestamp":1501027821000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Prevention of Ophthalmia Neonatorum Caused by\n            <i>Neisseria gonorrhoeae<\/i>\n            Using a Fatty Acid-Based Formulation"],"prefix":"10.1128","volume":"8","author":[{"given":"Colin P.","family":"Churchward","sequence":"first","affiliation":[{"name":"School of Life Sciences, Pharmacy, and Chemistry, Kingston University, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raid G.","family":"Alany","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Pharmacy, and Chemistry, Kingston University, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth S.","family":"Kirk","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Pharmacy, and Chemistry, Kingston University, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Walker","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Pharmacy, and Chemistry, Kingston University, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-3984","authenticated-orcid":false,"given":"Lori A. 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