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In the case of rod-shaped bacteria, the poles of the cell are potential weak points in the cell envelope due to the high curvature of the layers and the need to break and reform the cell envelope at the division plane as the cells divide. We have found that TipN, a factor required for correct division and cell pole development in\n                    <jats:named-content content-type=\"genus-species\">Caulobacter crescentus<\/jats:named-content>\n                    , is also needed for maintaining normal levels of resistance to cell wall-targeting antibiotics such as vancomycin and cefixime, which interfere with peptidoglycan synthesis. Since TipN is normally located at the poles of the cell and at the division plane just before cells complete division, our results suggest that it is involved in stabilization of these weak points of the cell envelope as well as its other roles inside the cell.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00538-20","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T10:08:48Z","timestamp":1588586928000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics"],"prefix":"10.1128","volume":"11","author":[{"given":"Simon-Ulysse","family":"Vallet","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Medicine, Institute of Genetics and Genomics in Geneva (iG3), Faculty of Medicine\/CMU, University of 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