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The side effects of chemotherapy highlight the need for better BL treatments. Many BL tumors contain EBV, and our goal is to determine what makes EBV-positive BL different from EBV-negative BL. This may lead to more specific treatments for both types. All cases of BL require overexpression of\n                    <jats:italic>MYC<\/jats:italic>\n                    . Mice engineered to express EBV LMP2A along with\n                    <jats:italic>MYC<\/jats:italic>\n                    (LMP2A\/\u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    mice) develop tumors much more quickly than mice only expressing\n                    <jats:italic>MYC<\/jats:italic>\n                    (\u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    mice). Blocking degradation of the cell cycle inhibitor protein p27\n                    <jats:sup>Kip1<\/jats:sup>\n                    in LMP2A\/\u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    mice causes tumors to develop later than in \u03bb-\n                    <jats:italic>MYC<\/jats:italic>\n                    mice, showing that p27\n                    <jats:sup>Kip1<\/jats:sup>\n                    degradation may play a larger role in EBV-positive BL than EBV-negative BL. Furthermore, our studies suggest the cell cycle is an attractive target as a treatment option for LMP2A-positive cancers in humans.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00548-19","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T06:41:36Z","timestamp":1555310496000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Two Pathways of p27\n                    <sup>Kip1<\/sup>\n                    Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A"],"prefix":"10.1128","volume":"10","author":[{"given":"Richard P.","family":"Sora","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-6217","authenticated-orcid":false,"given":"Richard","family":"Longnecker","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"1898","volume-title":"Fields virology","author":"Longnecker R","year":"2013","unstructured":"Longnecker R, Kieff E, Cohen J. 2013. 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