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These infections result in high rates of mortality, as treatment and diagnostic options remain limited. In healthy individuals, neutrophilic granulocytes are critical for elimination of\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    from the host; however, the exact extracellular mechanism of neutrophil-mediated antifungal activity remains unresolved. Here, we present a mode of antifungal defense employed by human neutrophils against\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    not previously described. We found that extracellular vesicles produced by neutrophils in response to\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    infection are able to associate with the fungus, limit growth, and elicit cell damage by delivering antifungal cargo. In the end, antifungal extracellular vesicle biology provides a significant step forward in our understanding of\n                    <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n                    host pathogenesis and opens up novel diagnostic and therapeutic possibilities.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00596-20","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T09:41:03Z","timestamp":1586770863000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Human Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus"],"prefix":"10.1128","volume":"11","author":[{"given":"Iordana A.","family":"Shopova","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Friedrich Schiller University, Jena, Germany"},{"name":"Department of Molecular and Applied Microbiology, Leibniz 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