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A major breakthrough in understanding\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      pathogenicity was the discovery of candidalysin, the first cytolytic peptide toxin identified in a human pathogenic fungus. Secreted by\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      hyphae and encoded by the\n                      <jats:italic toggle=\"yes\">ECE1<\/jats:italic>\n                      gene, this 31-amino acid peptide integrates into and permeabilizes host cell membranes, causing damage across diverse cell types. Beyond its cytolytic activity, candidalysin can trigger potent innate immune responses in epithelial cells, macrophages, and neutrophils. Additionally, candidalysin plays a key role in nutrient acquisition during infection. This review explores the biology of candidalysin, its role in host cell activation, and extends the discussion to non-candidalysin Ece1p peptides, shedding light on their emerging significance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.00603-24","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T09:00:22Z","timestamp":1745830822000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Candidalysin biology and activation of host cells"],"prefix":"10.1128","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6221-7763","authenticated-orcid":true,"given":"L\u00e9a","family":"Lortal","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220mzb33","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King\u2019s College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Lyon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220mzb33","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King\u2019s College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob L.","family":"Sprague","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans Kn\u00f6ll Institute (HKI)","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Sonnberger","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/055s37c97","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans Kn\u00f6ll Institute (HKI)","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia K. 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