{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:54:13Z","timestamp":1791554053166,"version":"4.3.4"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"HHS | National Institutes of Health","award":["K08AI132720"],"award-info":[{"award-number":["K08AI132720"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Dissemination from one organ system to another is common to many pathogens and often the key process separating simple illness from fatal infection. The pathogenic\n                      <jats:italic toggle=\"yes\">Cryptococcus<\/jats:italic>\n                      species offer a prime example. Cryptococcal infection is thought to begin in the lungs, as a mild or asymptomatic pneumonia. However, bloodborne dissemination from the lungs to the brain is responsible for the most devastating forms of infection. As with other disseminating infections, the transition likely depends on rare but crucial events, such as the crossing of a tissue barrier. By their nature, these events are difficult to study. Francis et al. (mBio 15:e03078-23, 2024,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/mbio.03078-23\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/mbio.03078-23<\/jats:ext-link>\n                      ) have addressed this difficulty by developing a powerful imaging pipeline to scan through unprecedented volumes of tissue from mice infected with\n                      <jats:italic toggle=\"yes\">Cryptococcus<\/jats:italic>\n                      at multiple stages of infection. Their observations challenge some of our basic assumptions about cryptococcal pathogenesis, including when and how the organism reaches the bloodstream and the central nervous system.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.00657-24","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T09:01:18Z","timestamp":1720429278000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["A deep cut into early cryptococcal pathogenesis"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-6921","authenticated-orcid":true,"given":"J. Muse","family":"Davis","sequence":"first","affiliation":[{"name":"Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa","place":["Iowa City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4801-3.00264-2"},{"key":"e_1_3_1_3_2","first-page":"149","volume-title":"Human torulosis: a clinical, pathological and microbiological study, with a report of thirteen cases","author":"Cox LB","year":"1946","unstructured":"Cox LB, Tolhurst JC. 1946. Human torulosis: a clinical, pathological and microbiological study, with a report of thirteen cases, p 149. Melbourne University Press, Melbourne and London."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-023-01073-4"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010697"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00506-16"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12027"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00240-09"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03078-23"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2018_145"},{"key":"e_1_3_1_11_2","first-page":"584","volume-title":"Cryptococcosis, in Infectious diseases of the dog and cat","author":"Malik R","year":"2006","unstructured":"Malik R, Krockenberger MO. 2006. Edited by Greene C. Cryptococcosis, in Infectious diseases of the dog and cat, p 584\u2013598. Elsevier, St. Louis."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00483-19"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.389676"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04315-22"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpmc.78"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02183-16"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00554-13"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/341564"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3423"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-017-1573-x"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.03.015"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.00657-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.00657-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:37:40Z","timestamp":1791553060000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.00657-24"}},"subtitle":[],"editor":[{"given":"Luis R.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,14]]}},"alternative-id":["10.1128\/mbio.00657-24"],"URL":"https:\/\/doi.org\/10.1128\/mbio.00657-24","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,14]]},"assertion":[{"value":"2024-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00657-24"}}