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A key requirement of invasion is the ability of the parasite to migrate through tissue layers. Here, we systematically looked for differences in protein phosphorylation between control parasites and a previously identified hyperadherent\n            <jats:named-content content-type=\"genus-species\">E. histolytica<\/jats:named-content>\n            cell line that has reduced motility. We identified EhCoactosin, an actin-binding protein not previously known to be phosphoregulated, as one of the differentially phosphorylated proteins in\n            <jats:named-content content-type=\"genus-species\">E. histolytica<\/jats:named-content>\n            and demonstrated that EhCoactosin phosphorylation functions in control of cell membrane dynamics and amoebic motility. This and the additional differentially phosphorylated proteins reported lay the groundwork for identifying kinases and phosphatases that regulate tissue invasiveness.\n          <\/jats:p>","DOI":"10.1128\/mbio.00660-20","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T13:10:45Z","timestamp":1596460245000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility"],"prefix":"10.1128","volume":"11","author":[{"given":"Muhammad M.","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, Vermont, USA"},{"name":"Cellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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