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Antimicrobial agents that target multiple infectious pathogens are ideal candidates to reduce the number of newly acquired STIs. The antimicrobial and immunoregulatory properties of GML make it an excellent candidate to fit this critical need. Previous studies established the safety profile and antibacterial activity of GML against both Gram-positive and Gram-negative bacteria. GML protected against high-dose SIV infection and reduced inflammation, which can exacerbate disease, during infection. We found that GML inhibits HIV-1 and other human-pathogenic viruses (yellow fever virus, mumps virus, and Zika virus), broadening its antimicrobial range. Because GML targets diverse infectious pathogens, GML may be an effective agent against the broad range of sexually transmitted pathogens. Further, our data show that reutericyclin, a GML analog expressed by some lactobacillus species, also inhibits HIV-1 replication and thus may contribute to the protective effect of\n            <jats:italic>Lactobacillus<\/jats:italic>\n            in HIV-1 transmission.\n          <\/jats:p>","DOI":"10.1128\/mbio.00686-20","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T14:08:48Z","timestamp":1588601328000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Glycerol Monolaurate, an Analogue to a Factor Secreted by\n            <i>Lactobacillus<\/i>\n            , Is Virucidal against Enveloped Viruses, Including HIV-1"],"prefix":"10.1128","volume":"11","author":[{"given":"Jennifer L.","family":"Welch","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA"},{"name":"Medical Service, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, USA"},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA"},{"name":"Medical Service, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, USA"},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-6493","authenticated-orcid":false,"given":"Chioma M.","family":"Okeoma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Stony Brook University School of Medicine, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Schlievert","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack T.","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA"},{"name":"Medical Service, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, USA"},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(21)00449-6"},{"key":"e_1_3_3_3_2","first-page":"454","article-title":"Effectiveness of condoms in preventing sexually transmitted infections","volume":"82","author":"Holmes KK","year":"2004","unstructured":"Holmes KK, Levine R, Weaver M. 2004. 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