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A recent strong advocacy campaign driven by the World Health Organization and the International Vaccine Institute has highlighted the urgent need for a GAS vaccine. One significant obstacle in GAS vaccine development is the lack of a widely used animal model to assess vaccine efficacy. Researchers in the field use a wide range of murine models of infection and\n            <jats:italic>in vitro<\/jats:italic>\n            assays, sometimes yielding conflicting results. Here we present the nonhuman primate pharyngeal infection model as a tool to assess vaccine-induced protection against colonization and clinical symptoms of pharyngitis and tonsillitis. We have tested the efficacy of an experimental vaccine candidate with promising results. We believe that the utilization of this valuable tool by the GAS vaccine research community could significantly accelerate the realization of a safe and effective GAS vaccine for humans.\n          <\/jats:p>","DOI":"10.1128\/mbio.00693-19","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T14:52:14Z","timestamp":1556549534000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":79,"title":["An Experimental Group A\n            <i>Streptococcus<\/i>\n            Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model"],"prefix":"10.1128","volume":"10","author":[{"given":"Tania","family":"Rivera-Hernandez","sequence":"first","affiliation":[{"name":"Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD, Australia"},{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, 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