{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:39:10Z","timestamp":1753882750982,"version":"3.41.2"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T00:00:00Z","timestamp":1379980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The Gram-negative bacterium\n            <jats:named-content content-type=\"genus-species\">Burkholderia pseudomallei<\/jats:named-content>\n            is the causative agent of melioidosis, a serious infectious disease of humans and animals. Once considered an esoteric tropical disease confined to Southeast Asia and northern Australia, research on\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            has recently gained global prominence due to its classification as a potential bioterrorism agent by countries such as the United States and also by increasing numbers of case reports from regions where it is not endemic. An environmental bacterium typically found in soil and water, assessing the true global prevalence of melioidosis is challenged by the fact that clinical symptoms associated with\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            infection are extremely varied and may be confused with diverse conditions such as lung cancer, tuberculosis, or\n            <jats:italic>Staphyloccocus aureus<\/jats:italic>\n            infection. These diagnostic challenges, coupled with lack of awareness among clinicians, have likely contributed to underdiagnosis and the high mortality rate of melioidosis, as initial treatment is often either inappropriate or delayed. Even after antibiotic treatment, relapses are frequent, and after resolution of acute symptoms, chronic melioidosis can also occur, and the symptoms can persist for months to years. In a recent article, Price et al. [mBio 4(4):e00388-13, 2013, doi:10.1128\/mBio.00388-13] demonstrate how comparative genomic sequencing can reveal the repertoire of genetic changes incurred by\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            during chronic human infection. Their results have significant clinical ramifications and highlight\n            <jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>\n            \u2019s ability to survive in a wide range of potential niches within hosts, through the acquisition of genetic adaptations that optimize fitness and resource utilization.\n          <\/jats:p>","DOI":"10.1128\/mbio.00709-13","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T08:34:19Z","timestamp":1380098059000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Less Is More: Burkholderia pseudomallei and Chronic Melioidosis"],"prefix":"10.1128","volume":"4","author":[{"given":"Tannistha","family":"Nandi","sequence":"first","affiliation":[{"name":"Genome Institute of Singapore, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Tan","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Singapore, Republic of Singapore"},{"name":"Duke-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore"},{"name":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403302101"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211915"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111020108"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000845"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000900"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90333-X"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13374-0"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1385"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00388-13"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602138103"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evq003"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00930-12"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.49"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036507"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000725"},{"key":"e_1_3_1_17_2","first-page":"331","article-title":"Pulmonary melioidosis. Observations in thirty-nine cases","volume":"112","author":"Everett ED","year":"1975","unstructured":"EverettED NelsonRA . 1975. Pulmonary melioidosis. Observations in thirty-nine cases. Am. Rev. Respir. Dis. 112:331\u2013340.","journal-title":"Am. Rev. Respir. 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