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Here, we present evidence that an intact core\n            <jats:italic>N<\/jats:italic>\n            -glycan structure is required for\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            pathogenicity by systematically analyzing\n            <jats:italic>alg3\u0394, alg9\u0394<\/jats:italic>\n            , and\n            <jats:italic>alg12\u0394<\/jats:italic>\n            strains that have defects in lipid-linked\n            <jats:italic>N-<\/jats:italic>\n            glycan assembly and in\n            <jats:italic>in vivo<\/jats:italic>\n            virulence. The\n            <jats:italic>alg<\/jats:italic>\n            null mutants producing truncated core\n            <jats:italic>N<\/jats:italic>\n            -glycans were defective in inducing host cell death after phagocytosis, which is triggered as a mechanism of pulmonary escape and dissemination of\n            <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n            , thus becoming inactive in causing fatal infection. The results clearly demonstrated the critical features of the\n            <jats:italic>N<\/jats:italic>\n            -glycan structure in mediating the interaction with host cells during fungal infection. The delineation of the roles of protein glycosylation in fungal pathogenesis not only provides insight into the glycan-based fungal infection mechanism but also will aid in the development of novel antifungal agents.\n          <\/jats:p>","DOI":"10.1128\/mbio.00711-20","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T13:50:20Z","timestamp":1589205020000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Core\n            <i>N<\/i>\n            -Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death"],"prefix":"10.1128","volume":"11","author":[{"given":"Eun Jung","family":"Thak","sequence":"first","affiliation":[{"name":"Department of Life Science, Chung-Ang University, Seoul, South 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