{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:15:46Z","timestamp":1791504946202,"version":"4.3.4"},"reference-count":20,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01 AI 137424"],"award-info":[{"award-number":["R01 AI 137424"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Survivors of Powassan encephalitis often have persistent neurological disease. A new mouse model replicates some elements of the human disease and demonstrates the presence of viral RNA in the brain as well as myelitis more than 2 mo after the acute infection. The related tick-borne encephalitis and West Nile Neuroinvasive Disease (WNND) also have common neurological sequelae, and models for these better-studied diseases provide evidence for prolonged virus, RNA, and inflammation in some cases, in addition to damage from the acute encephalitic disease. A better understanding of the biological basis for persistent signs and symptoms after Powassan encephalitis, currently a rare disease, could benefit from further studies of the more prevalent flaviviral encephalitides.<\/jats:p>","DOI":"10.1128\/mbio.00712-23","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T14:54:56Z","timestamp":1687272896000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Powassan virus persistence after acute infection"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-8663","authenticated-orcid":true,"given":"Sam R.","family":"Telford","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Global Health; Tufts Lyme Disease Initiative, Tufts University , North Grafton, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-1534","authenticated-orcid":true,"given":"Anne L.","family":"Piantadosi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine , Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03606-22"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1183"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2017.12.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2022.03.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12485"},{"key":"e_1_3_2_7_2","first-page":"1419","article-title":"Powassan encephalitis: a case report with neuropathology and literature review","volume":"161","author":"Gholam BI","year":"1999","unstructured":"Gholam BI , Puksa S , Provias JP . 1999. Powassan encephalitis: a case report with neuropathology and literature review. CMAJ 161:1419\u20131422.","journal-title":"CMAJ"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071420"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-248"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-3527(03)61008-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.01.014"},{"key":"e_1_3_2_12_2","first-page":"352","article-title":"Persistence of tick-borne encephalitis virus in monkeys. III. phenotypes of the persisting virus","volume":"25","author":"Pogodina VV","year":"1981","unstructured":"Pogodina VV , Levina LS , Fokina GI , Koreshkova GV , Malenko GV , Bochkova NG , Rzhakhova OE . 1981. Persistence of tick-borne encephalitis virus in monkeys. III. phenotypes of the persisting virus. 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