{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:43:36Z","timestamp":1780094616322,"version":"3.54.0"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","award":["1020388"],"award-info":[{"award-number":["1020388"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]},{"name":"HHS | National Institutes of Health","award":["R01AI143689"],"award-info":[{"award-number":["R01AI143689"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Candida parapsilosis<\/jats:italic>\n            is an opportunistic fungal pathogen with increasing incidence in hospital settings worldwide; however, we lack a comprehensive understanding of the mechanisms promoting its virulence and drug resistance. Bergin et al. systematically quantify the frequency and effect of copy number variation (CNV) across 170 diverse clinical and environmental isolates of\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            (Bergin SA, Zhao F, Ryan AP, M\u00fcller CA, Nieduszynski CA, Zhai B, Rolling T, Hohl TM, Morio F, Scully J, Wolfe KH, Butler G, 2022, mBio,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/mbio.01777-22\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/mbio.01777-22<\/jats:ext-link>\n            ). Using a combination of both short- and long-read whole genome sequencing techniques, they determine the structure and copy number of two CNVs that arose recurrently throughout the evolution of these isolates. Each CNV predominantly amplifies one coding sequence (\n            <jats:italic>ARR3<\/jats:italic>\n            or\n            <jats:italic>RTA3<\/jats:italic>\n            ); however, the amplitude and recombination breakpoints are variable across the isolates. Amplification of\n            <jats:italic>RTA3<\/jats:italic>\n            correlates with drug resistance and deletion causes drug susceptibility. This study highlights the need for further research into the mechanisms and dynamics of CNV formation and the impact of these CNVs on virulence and drug resistance across diverse fungal pathogens.\n          <\/jats:p>","DOI":"10.1128\/mbio.00713-23","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:00:40Z","timestamp":1696338040000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Recurrent copy number variations in the human fungal pathogen\n            <i>Candida parapsilosis<\/i>"],"prefix":"10.1128","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3298-2400","authenticated-orcid":false,"given":"Anna","family":"Selmecki","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Minnesota Medical School , Minneapolis, Minnesota, 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