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Fungi have a remarkable ability to adapt to heat and pollution, and to disseminate via air, water ecosystems, or wildfire smoke. Their genetic plasticity can lead to thermotolerance, the ability to find new ecological niches, and fitness gains. Natural reservoirs of the fungal biomass, which are heavily affected by global warming, may serve as the environments from where new fungal diseases originate, as illustrated by the recent emergence of\n                      <jats:italic toggle=\"yes\">Candidozyma auris<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Rhodosporidiobolus fluvialis<\/jats:italic>\n                      . Moreover, global warming also affects human skin\/mucosal integrity and local or systemic immune responses, which could increase host susceptibility to fungal infections. This review examines the impact of global warming on the complex fungi-host interactions, which can lead to new challenges in mycology, and discusses possible mitigation strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/mbio.00750-26","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:21:17Z","timestamp":1782912077000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["mGem: A perfect storm in the era of global warming\u2014the convergence between thermotolerant fungi and altered immunity"],"prefix":"10.1128","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1023-5597","authenticated-orcid":true,"given":"Frederic","family":"Lamoth","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019whta54","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne","place":["Lausanne, Switzerland"]},{"id":[{"id":"https:\/\/ror.org\/02z31g829","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Microbiology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne","place":["Lausanne, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-2940","authenticated-orcid":true,"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04twxam07","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17908"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2025_305"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2024.11.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(24)00039-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41558-022-01426-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04246"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Buckley M. 2008. 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