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As the number of\n            <jats:italic>Aspergillus<\/jats:italic>\n            -infected patients treated with echinocandins is rising, clinical observations of drug resistance are also increasing, indicating an emerging global health threat. Our knowledge regarding the development of clinical echinocandin resistance is largely derived from\n            <jats:italic>Candida<\/jats:italic>\n            spp., while little is known about resistance in\n            <jats:italic>Aspergillus.<\/jats:italic>\n            Therefore, it is important to understand the specific cellular responses raised by\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            against echinocandins. We discovered a new mechanism of resistance in\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            that is independent of the well-characterized\n            <jats:italic>FKS<\/jats:italic>\n            mutation mechanism observed in\n            <jats:italic>Candida<\/jats:italic>\n            . This study identified an off-target effect of CAS, i.e., ROS production, and integrated oxidative stress and sphingolipid alterations into a novel mechanism of resistance. This stress-induced response has implications for drug resistance and\/or tolerance mechanisms in other fungal pathogens.\n          <\/jats:p>","DOI":"10.1128\/mbio.00779-19","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T12:54:27Z","timestamp":1559566467000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["Stress-Induced Changes in the Lipid Microenvironment of \u03b2-(1,3)-\n            <scp>d<\/scp>\n            -Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus"],"prefix":"10.1128","volume":"10","author":[{"given":"Shruthi","family":"Satish","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"},{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Jim\u00e9nez-Ortigosa","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enriko","family":"Dolgov","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Denning","sequence":"additional","affiliation":[{"name":"National Aspergillosis Centre, Wythenshawe Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9493-6402","authenticated-orcid":false,"given":"Olaf","family":"Kniemeyer","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel A.","family":"Brakhage","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany"},{"name":"Department of Microbiology and Molecular Biology, Institute of Microbiology, Friedrich Schiller University, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.02.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof4030098"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ791"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01277-17"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00917-07"},{"key":"e_1_3_2_9_2","volume-title":"Abstr Adv Aspergillosis","author":"Satish S","year":"2018","unstructured":"Satish S, Jimenez-Ortigosa C, Perlin DS. 2018. 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