{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:41:11Z","timestamp":1791110471420,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Universitat de Valencia","award":["Contrato Atracci\u00f3de talent"],"award-info":[{"award-number":["Contrato Atracci\u00f3de talent"]}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["Subvenciones para la contrataci\u00f3n de personal investigador predoctoral"],"award-info":[{"award-number":["Subvenciones para la contrataci\u00f3n de personal investigador predoctoral"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2014-53823-P"],"award-info":[{"award-number":["SAF2014-53823-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["RTI2018-093426-B-100"],"award-info":[{"award-number":["RTI2018-093426-B-100"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["Ram\u00f3n y Cajal contract (RYC-2017-22895)"],"award-info":[{"award-number":["Ram\u00f3n y Cajal contract (RYC-2017-22895)"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:p>\n            Invasive candidiasis is an increasingly frequent cause of serious and often fatal infections. Understanding host defense is essential to design novel therapeutic strategies to boost immune protection against\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            . In this article, we delve into two new concepts that have arisen over the last years: (i) the delivery of myelopoiesis-inducing signals by microbial components directly sensed by hematopoietic stem and progenitor cells (HSPCs) and (ii) the concept of \u201ctrained innate immunity\u201d that may also apply to HSPCs. We demonstrate that dectin-1 ligation\n            <jats:italic>in vivo<\/jats:italic>\n            activates HSPCs and induces their differentiation to trained macrophages by a cell-autonomous indirect mechanism. This points to new mechanisms by which pathogen detection by HSPCs may modulate hematopoiesis in real time to generate myeloid cells better prepared to deal with the infection. Manipulation of this process may help to boost the innate immune response during candidiasis.\n          <\/jats:p>","DOI":"10.1128\/mbio.00781-20","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T14:09:27Z","timestamp":1592834967000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs\n            <i>In Vivo<\/i>\n            and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism"],"prefix":"10.1128","volume":"11","author":[{"given":"Cristina","family":"Bono","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universitat de Val\u00e8ncia, Burjassot, Spain"},{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de Val\u00e8ncia, Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universitat de Val\u00e8ncia, Burjassot, Spain"},{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de Val\u00e8ncia, Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Meg\u00edas","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Universitat de Val\u00e8ncia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gozalbo","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universitat de Val\u00e8ncia, Burjassot, Spain"},{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de Val\u00e8ncia, Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-1963","authenticated-orcid":false,"given":"Alberto","family":"Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universitat de Val\u00e8ncia, Burjassot, Spain"},{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de Val\u00e8ncia, Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-5678","authenticated-orcid":false,"given":"M. Luisa","family":"Gil","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universitat de Val\u00e8ncia, Burjassot, Spain"},{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de Val\u00e8ncia, Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053318"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2741\/4388"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.008"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.155"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.09.054"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343833"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.01.011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01382.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024761"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343403"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2016.01.005"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2017.0398"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1110"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.01.007"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501231"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600813"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.06.013"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.45"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.06.002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.06.004"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12104"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.09.047"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.07.002"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.006"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.031"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000149"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00309"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-466268"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.05.004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2003.09.020"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46740-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2007.0085"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00781-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00781-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T02:47:10Z","timestamp":1646707630000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.00781-20"}},"subtitle":[],"editor":[{"suffix":"Jr.","given":"Floyd L.","family":"Wormley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6,30]]}},"alternative-id":["10.1128\/mBio.00781-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.00781-20","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"assertion":[{"value":"2020-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00781-20"}}