{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:47:51Z","timestamp":1790628471775,"version":"4.1.0"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000040","name":"Gouvernement du Canada | Agriculture and Agri-Food Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,6,25]]},"abstract":"<jats:p>\n                    <jats:italic>Fusarium<\/jats:italic>\n                    head blight caused by the fungal pathogen\n                    <jats:named-content content-type=\"genus-species\">Fusarium graminearum<\/jats:named-content>\n                    is a devastating disease of cereal crops worldwide, with limited effective chemical treatments available. Here we show that the natural alkaloid compound antofine can inhibit fusarium head blight in wheat. Using yeast genomic screening, we identified the TOR pathway component RRD2 as a target of antofine that is also required for\n                    <jats:named-content content-type=\"genus-species\">F. graminearum<\/jats:named-content>\n                    pathogenicity.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00792-19","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T10:20:12Z","timestamp":1560162012000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum"],"prefix":"10.1128","volume":"10","author":[{"given":"Christopher","family":"Mogg","sequence":"first","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bonner","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Schernthaner","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biology, Carleton University, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell","family":"Desveaux","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2005.01.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1904"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.07.026"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2015.03.011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.06.036"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2008.01.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO.2000.90.1.17"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/19440040903515942"},{"key":"e_1_3_2_10_2","first-page":"198","article-title":"Interference of selected fungicides, plant growth retardants as well as piperonyl butoxide and 1-aminobenzotriazole in trichothecene production of Fusarium graminearum (strain 4528) in vitro","volume":"106","author":"Matthies A","year":"1999","unstructured":"Matthies A, Walker F, Buchenauer H. 1999. 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Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors. 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