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Invasive pulmonary aspergillosis is the most serious pathology in terms of patient outcome and treatment, with a high mortality rate ranging from 50% to 95% primarily affecting immunocompromised patients. Azoles have been used for many years as the main antifungal agents to treat and prevent invasive aspergillosis. However, there were several reports of evolution of clinical azole resistance in the last decade. Caspofungin, a noncompetitive \u03b2-1,3-glucan synthase inhibitor, has been used against\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            , but it is fungistatic and is recommended as second-line therapy for invasive aspergillosis. More information about caspofungin tolerance and resistance is necessary in order to refine antifungal strategies that target the fungal cell wall. Here, we screened a transcription factor (TF) deletion library for TFs that can mediate caspofungin tolerance and resistance. We have identified 11 TFs that are important for caspofungin sensitivity and\/or for the\n            <jats:underline>c<\/jats:underline>\n            aspofungin\n            <jats:underline>p<\/jats:underline>\n            aradoxical\n            <jats:underline>e<\/jats:underline>\n            ffect (CPE). These TFs encode proteins involved in the basal modulation of the RNA polymerase II initiation sites, calcium metabolism or cell wall remodeling, and mitochondrial respiratory function. The study of those genes regulated by TFs identified in this work will provide a better understanding of the signaling pathways that are important for caspofungin tolerance and resistance.\n          <\/jats:p>","DOI":"10.1128\/mbio.00816-20","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T14:17:27Z","timestamp":1592230647000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect"],"prefix":"10.1128","volume":"11","author":[{"given":"Clara","family":"Valero","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo Ribeir\u00e3o Preto, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana 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