{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:10:23Z","timestamp":1774789823245,"version":"3.50.1"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["098051"],"award-info":[{"award-number":["098051"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2016,7,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Mice harboring a mutation in the gene encoding gastric intrinsic factor (Gif), a protein essential for the absorption of vitamin B\n            <jats:sub>12<\/jats:sub>\n            \/cobalamin (Cbl), have potential as a model to explore the role of vitamins in infection. The levels of Cbl in the blood of\n            <jats:italic>Gif<\/jats:italic>\n            <jats:sup>tm1a\/tm1a<\/jats:sup>\n            mutant mice were influenced by the maternal genotype, with offspring born to heterozygous (high Cbl, F\n            <jats:sub>1<\/jats:sub>\n            ) mothers exhibiting a significantly higher serum Cbl level than those born to homozygous (low Cbl, F\n            <jats:sub>2<\/jats:sub>\n            ) equivalents. Low Cbl levels correlated with susceptibility to an infectious challenge with\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovar Typhimurium or\n            <jats:named-content content-type=\"genus-species\">Citrobacter rodentium<\/jats:named-content>\n            , and this susceptibility phenotype was moderated by Cbl administration. Transcriptional and metabolic profiling revealed that Cbl deficient mice exhibited a bioenergetic shift similar to a metabolic phenomenon commonly found in cancerous cells under hypoxic conditions known as the Warburg effect, with this metabolic effect being exacerbated further by infection. Our findings demonstrate a role for Cbl in bacterial infection, with potential general relevance to dietary deficiency and infection susceptibility.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            Malnutrition continues to be a major public health problem in countries with weak infrastructures. In communities with a high prevalence of poor diet, malnourishment and infectious disease can impact vulnerable individuals such as pregnant women and children. Here, we describe a highly flexible murine model for monitoring maternal and environmental influences of vitamin B\n            <jats:sub>12<\/jats:sub>\n            metabolism. We also demonstrate the potential importance of vitamin B\n            <jats:sub>12<\/jats:sub>\n            in controlling susceptibility to bacterial pathogens such as\n            <jats:named-content content-type=\"genus-species\">C. rodentium<\/jats:named-content>\n            and\n            <jats:italic>S<\/jats:italic>\n            .\u00a0Typhimurium. We postulate that this model, along with similarly vitamin deficient mice, could be used to further explore the mechanisms associated with micronutrients and susceptibility to diseases, thereby increasing our understanding of disease in the malnourished.\n          <\/jats:p>","DOI":"10.1128\/mbio.00830-16","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T17:13:59Z","timestamp":1466702039000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B\n            <sub>12<\/sub>\n            )-Defective Mice Is Subject to Maternal Influences"],"prefix":"10.1128","volume":"7","author":[{"given":"Lynda","family":"Mottram","sequence":"first","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United 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