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We characterized the bacterial microbiomes of North American volunteers at four skin sites and the mouth. We also collected extensive subject metadata and measured several host physiological parameters. Integration of host and microbial features showed that the skin microbiome was predominantly associated with demographic, lifestyle, and physiological factors. Furthermore, we uncovered reproducible associations between chronological age, skin aging, and members of the genus\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    . Our work provides new understanding of the role of host selection and lifestyle in shaping skin microbiome composition. It also contributes to a more comprehensive appreciation of the factors that drive interindividual skin microbiome variation.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00839-19","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T06:41:19Z","timestamp":1561963279000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":171,"title":["New Insights into the Intrinsic and Extrinsic Factors That Shape the Human Skin Microbiome"],"prefix":"10.1128","volume":"10","author":[{"given":"Pedro A.","family":"Dimitriu","sequence":"first","affiliation":[{"name":"Microbiome Insights, Inc., Vancouver, British Columbia, Canada"},{"name":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Iker","sequence":"additional","affiliation":[{"name":"Amway Corporation, Ada, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kausar","family":"Malik","sequence":"additional","affiliation":[{"name":"Amway Corporation, Ada, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Leung","sequence":"additional","affiliation":[{"name":"Microbiome Insights, Inc., Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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