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Here we present data showing that the transcriptome of the important human pathogen\n            <jats:named-content content-type=\"genus-species\">Streptococcus pyogenes<\/jats:named-content>\n            shows extensive remodeling during\n            <jats:italic>in vivo<\/jats:italic>\n            growth, resulting in, among many other differentially expressed genes and pathways, a significant increase in genes involved in acquiring iron from host heme. Data show that HupY, previously characterized as an adhesin in both\n            <jats:named-content content-type=\"genus-species\">S. pyogenes<\/jats:named-content>\n            and the related pathogen\n            <jats:named-content content-type=\"genus-species\">Streptococcus agalactiae<\/jats:named-content>\n            , binds heme and affects intracellular iron concentrations. HupY, a protein with no known heme binding domains, represents a novel heme binding protein playing an important role in bacterial iron homeostasis as well as vaginal colonization.\n          <\/jats:p>","DOI":"10.1128\/mbio.00848-19","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T13:54:27Z","timestamp":1561384467000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Transcriptomic Analysis of Streptococcus pyogenes Colonizing the Vaginal Mucosa Identifies\n            <i>hupY<\/i>\n            , an MtsR-Regulated Adhesin Involved in Heme Utilization"],"prefix":"10.1128","volume":"10","author":[{"given":"Laura C. 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