{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:56Z","timestamp":1789603256800,"version":"build-2803163510"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI124723"],"award-info":[{"award-number":["AI124723"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI060519"],"award-info":[{"award-number":["AI060519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,8,25]]},"abstract":"<jats:p>\n                    Cells that are infected with the parasite\n                    <jats:named-content content-type=\"genus-species\">Toxoplasma gondii<\/jats:named-content>\n                    exhibit heightened migratory activity, which facilitates dissemination of the infection throughout the body. In this report, we identify a new mechanism used by\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    to hijack its host cell and increase its mobility. We further show that the ability of\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    to increase host cell migration involves not the enzymatic activity of IRE1 but rather IRE1 engagement with actin cytoskeletal remodeling. Depletion of IRE1 from infected host cells reduces their migration\n                    <jats:italic>in vitro<\/jats:italic>\n                    and significantly hinders dissemination of\n                    <jats:italic>Toxoplasma in vivo<\/jats:italic>\n                    . Our findings reveal a new mechanism underlying host-pathogen interactions, demonstrating how host cells are co-opted to spread a persistent infection around the body.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00915-20","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:43:28Z","timestamp":1594028608000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Toxoplasma gondii Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells"],"prefix":"10.1128","volume":"11","author":[{"given":"Leonardo","family":"Augusto","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA"},{"name":"Department of Pharmacology &amp; Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Martynowicz","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth H.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada S.","family":"Alakhras","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Wek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; 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