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Secondary bacterial coinfection by organisms such as\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            is the most common complication of primary IAV infection and is associated with high levels of morbidity and mortality. Here, we report the first identified\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            factor (lipase 1) that enhances IAV replication during infection via positive modulation of virus budding. The effect is observed\n            <jats:italic>in vivo<\/jats:italic>\n            in embryonated hen\u2019s eggs and greatly enhances the yield of a vaccine strain, a finding that could be applied to address global shortages of influenza vaccines.\n          <\/jats:p>","DOI":"10.1128\/mbio.00975-20","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T13:43:28Z","timestamp":1594043008000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Staphylococcus aureus Lipase 1 Enhances Influenza A Virus Replication"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-6060","authenticated-orcid":false,"given":"Mariya I.","family":"Goncheva","sequence":"first","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Conceicao","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2874-7822","authenticated-orcid":false,"given":"Stephen W.","family":"Tuffs","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Lee","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlynne","family":"Quigg-Nicol","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Bennet","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Sargison","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Pickering","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Hussain","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Gill","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette M.","family":"Dutia","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0872-9440","authenticated-orcid":false,"given":"Paul","family":"Digard","sequence":"additional","affiliation":[{"name":"The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-8468","authenticated-orcid":false,"given":"J. 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