{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:18:34Z","timestamp":1791177514292,"version":"4.1.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The biocide triclosan is used in many personal care products, including toothpastes, soaps, clothing, and medical equipment. Consequently, it is present as a contaminant in the environment and has been detected in some human fluids, including serum, urine, and milk.\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            is an opportunistic pathogen that colonizes the noses and throats of approximately 30% of the population. Colonization with\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            is known to be a risk factor for several types of infection. Here we demonstrate that triclosan is commonly found in the nasal secretions of healthy adults and the presence of triclosan trends positively with nasal colonization by\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            . We demonstrate that triclosan can promote the binding of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            to host proteins such as collagen, fibronectin, and keratin, as well as inanimate surfaces such as plastic and glass. Lastly, triclosan-exposed rats are more susceptible to nasal colonization with\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            . These data reveal a novel factor that influences the ability of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            to bind surfaces and alters\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            nasal colonization.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            Triclosan has been used as a biocide for over 40\u00a0years, but the broader effects that it has on the human microbiome have not been investigated. We demonstrate that triclosan is present in nasal secretions of a large portion of a test population and its presence correlates with\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            nasal colonization. Triclosan also promotes the binding of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            to human proteins and increases the susceptibility of rats to nasal colonization by\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            . These findings are significant because\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            colonization is a known risk factor for the development of several types of infections. Our data demonstrate the unintended consequences of unregulated triclosan use and contribute to the growing body of research demonstrating inadvertent effects of triclosan on the environment and human health.\n          <\/jats:p>","DOI":"10.1128\/mbio.01015-13","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T06:36:14Z","timestamp":1397025374000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Triclosan Promotes Staphylococcus aureus Nasal Colonization"],"prefix":"10.1128","volume":"5","author":[{"given":"Adnan K.","family":"Syed","sequence":"first","affiliation":[{"name":"Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy G.","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise R.","family":"Boles","sequence":"additional","affiliation":[{"name":"Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.15.1763"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp159"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02254-5"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00056"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/es049071e"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10768"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287390600631706"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2006.08.007"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/es401919k"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/28970"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2005.01790.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11200"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211314109"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki447"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2004.5.281"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411293112207"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl450"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(03)00222-6"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08668"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002104"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0934-8840(11)80871-6"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/424521"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-032-8_19"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07772"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01015-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.01015-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:31:18Z","timestamp":1646710278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.01015-13"}},"subtitle":[],"editor":[{"given":"Eric","family":"Skaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Scott 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