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In this study, we uncovered a hierarchical cell death program utilized by infected cells to disrupt the intracellular niche of\n            <jats:named-content content-type=\"genus-species\">Burkholderia thailandensis<\/jats:named-content>\n            by limiting bacterial intercellular spread, host cell-cell fusion, and bacterial replication. In macrophages, combined loss of key PANoptosis components results in extensive\n            <jats:named-content content-type=\"genus-species\">B. thailandensis<\/jats:named-content>\n            infection-induced cell-cell fusion, bacterial replication, and increased cell death at later stages of infection compared with both wild-type (WT) and pyroptosis-deficient cells.\n          <\/jats:p>","DOI":"10.1128\/mbio.01059-21","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T08:30:52Z","timestamp":1624350652000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1904-4164","authenticated-orcid":true,"given":"David E.","family":"Place","sequence":"first","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1145-4430","authenticated-orcid":true,"given":"Shelbi","family":"Christgen","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Tuladhar","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vogel","sequence":"additional","affiliation":[{"name":"Animal Resources Center and the Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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