{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:49:10Z","timestamp":1768448950398,"version":"3.49.0"},"reference-count":52,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"CIFAR Azrieli Global Scholars"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Fungal pathogens are increasingly appreciated as a significant infectious disease challenge. Compared to bacteria, fungal cells are more closely related to human cells, and few classes of antifungal drugs are available. Combination therapy offers a potential solution to reduce the likelihood of resistance acquisition and extend the lifespan of existing antifungals. There has been recent interest in combining first-line drugs with small-molecule adjuvants. In a recent article, Alabi et al. identified 1,4-benzodiazepines as promising molecules to enhance azole activity in pathogenic\n            <jats:italic>Candida<\/jats:italic>\n            spp. (P. E. Alabi, C. Gautier, T. P. Murphy, X. Gu, M. Lepas, V. Aimanianda, J. K. Sello, I. V. Ene, 2023, mBio\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/mbio.00479-23\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/mbio.00479-23<\/jats:ext-link>\n            ). These molecules have no antifungal activity on their own but exhibited significant potentiation of fluconazole in azole-susceptible and -resistant isolates. Additionally, the 1,4-benzodiazepines increased the fungicidal activity of azoles that are typically fungistatic to\n            <jats:italic>Candida<\/jats:italic>\n            spp., inhibited filamentation (a virulence-associated trait), and accordingly increased host survival in\n            <jats:italic>Galleria mellonella<\/jats:italic>\n            . This research thus provides another encouraging step on the critical pathway toward reducing mortality due to antimicrobial resistance.\n          <\/jats:p>","DOI":"10.1128\/mbio.01073-23","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T13:00:13Z","timestamp":1690981213000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Powering up antifungal treatment: using small molecules to unlock the potential of existing therapies"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-8865","authenticated-orcid":true,"given":"Rebecca S.","family":"Shapiro","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, University of Guelph , Guelph, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-9356","authenticated-orcid":true,"given":"Aleeza C.","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Manitoba , Winnipeg, Manitoba, Canada"},{"name":"Department of Statistics, University of Manitoba , Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00449-20"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_2_5_2","unstructured":"World Health Organization 2022 WHO fungal priority pathogens list to guide research development and public health action"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01172-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00237-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00199"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001692"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00248-12"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq479"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00720-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy358"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13739"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01811-20"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00045-10"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14472-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13211"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10327.2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.732223"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.68"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51711-x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1705155"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1305981"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr2992w"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.07.019"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705687"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1196300"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20183-3"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54160"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.10.018"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31308-1"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00479-23"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0085-z"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.103953"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813394106"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.4.546"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00616.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00179.x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2021.2025337"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000805"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14484"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaa055"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400093111"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008259"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00161-20"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007319"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.119.400199"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006609"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2013.57"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01073-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.01073-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T13:00:23Z","timestamp":1690981223000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01073-23"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Heitman","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":52,"alternative-id":["10.1128\/mbio.01073-23"],"URL":"https:\/\/doi.org\/10.1128\/mbio.01073-23","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]},"assertion":[{"value":"2023-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01073-23"}}