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In the gastrointestinal tract, mucus is composed of glycan-covered proteins, or mucins, which are secreted by goblet cells to form a protective gel-like structure above the epithelium. Low levels of mucin or alterations in mucin glycans are associated with inflammation and colitis in mice and humans. Although current literature links microbes to the modulation of goblet cells and mucins, the molecular pathways involved are not yet fully understood. Using a combination of gnotobiotic mice and mucus-secreting cell lines, we have identified a human-derived microbe,\n            <jats:named-content content-type=\"genus-species\">Bifidobacterium dentium<\/jats:named-content>\n            , which adheres to intestinal mucus and secretes metabolites that upregulate the major mucin MUC2 and modulate goblet cell function. Unlike other\n            <jats:italic>Bifidobacterium<\/jats:italic>\n            species,\n            <jats:italic>B. dentium<\/jats:italic>\n            does not extensively degrade mucin glycans and cannot grow on mucin alone. This work points to the potential of using\n            <jats:italic>B. dentium<\/jats:italic>\n            and similar mucin-friendly microbes as therapeutic agents for intestinal disorders with disruptions in the mucus barrier.\n          <\/jats:p>","DOI":"10.1128\/mbio.01087-19","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T11:01:58Z","timestamp":1560769318000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":239,"title":["Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-9932","authenticated-orcid":false,"given":"Melinda A.","family":"Engevik","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA"},{"name":"Department of Pathology, Texas Children\u2019s 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